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ea0041oc6.4 | Diabetes therapy & complications | ECE2016

LEA29Y expression in transgenic porcine islets prevents islet graft rejection in humanized mice without systemic immunosuppressive therapy

Wolf-van Buerck Lelia , Schuster Marion , Baehr Andrea , Klymiuk Nik , Wolf Eckhard , Seissler Jochen

Transplantation of pancreas or isolated Langerhans islets can cure type 1 diabetes. Xenografts from transgenic pigs represent a promising source to overcome the shortage of organ donors. We investigated the immunosuppressive effect of local LEA29Y expression (a high-affinity variant of CTLA4-Ig) by transplantation of neonatal porcine islet-like clusters (NPICCs) from INSLEA29Y transgenic pigs into humanized mice. NPICCs from 15 day-old pigs expressing LEA29Y und...

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ea0032p10 | Adrenal cortex | ECE2013

First phase insulin secretion is impaired by aldosterone excess in primary aldosteronism

Fischer Evelyn , Adolf Christian , Pallauf Anna , Then Cornelia , Bidlingmaier Martin , Beuschlein Felix , Seissler Jochen , Reincke Martin

Context: Primary aldosteronism (PA) represents the most frequent cause of a curable secondary arterial hypertension. Conflicting data have been published regarding the effect of aldosterone excess on glucose and lipid metabolism.Objective: Our aim was to analyze insulin sensitivity and beta cell function in a cohort of PA patients. Prospective follow-up investigations were performed in a subgroup of patients before and after adrenalectomy to assess the m...

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Endocrine Abstracts

LEA29Y expression in transgenic porcine islets prevents islet graft rejection in humanized mice without systemic immunosuppressive therapy

First phase insulin secretion is impaired by aldosterone excess in primary aldosteronism

BiosciAbstracts